Explore effective drugs similar to Invokana for managing type 2 diabetes. Learn about SGLT2 inhibitor alternatives, their mechanisms, and trusted brands in the USA.

What Is Invokana?

Invokana (canagliflozin) is an SGLT2 inhibitor used to manage type 2 diabetes by helping the kidneys remove excess glucose through urine. It also offers cardiovascular and kidney benefits, making it a valuable choice for diabetic patients with comorbid conditions.

However, Invokana isn’t the only drug in its class. Several FDA-approved medications offer similar benefits and mechanisms of action with slight variations in usage and safety profiles.

Top Drugs Similar to Invokana

1. Jardiance (empagliflozin)

• Also an SGLT2 inhibitor

• Offers significant cardiovascular and kidney protection

• Once-daily oral tablet

• Widely prescribed as an Invokana alternative

2. Farxiga (dapagliflozin)

• Dual-use: type 2 diabetes and heart failure

• Shown to reduce hospitalization for heart failure

• Also supports kidney health

3. Steglatro (ertugliflozin)

• Newer SGLT2 inhibitor

• Often used in combination with metformin or sitagliptin

• Similar side effect profile to Invokana

4. Synjardy

• A combination of Jardiance + metformin

• Useful for patients needing dual-action glucose control

• Reduces pill burden

5. Xigduo XR

• A combination of Farxiga + metformin extended-release

• Convenient for managing both fasting and post-meal blood sugar

Key Considerations When Switching

• Kidney function: Always monitor eGFR levels with SGLT2 inhibitors

• Heart health: Many alternatives provide cardio-protective benefits

• Cost and insurance: Generic options or combo drugs may offer better pricing

• Side effects: Includes urinary tract infections, dehydration, or ketoacidosis risks

Always consult with your healthcare provider before making any medication changes.